AHA ISC 2024 — Dr Anne Alexandrov (University of Tennessee Health Science Center, US) joins us to summarise the key findings from the Zero Degree Head Positioning in Hyperacute Large Artery Ischaemic Stroke (ZODIAC) trial (NCT03728738).

ZODIAC is a prospective randomized open blinded endpoint (PROBE) clinical trial investigating head positioning in hyperacute LVO ischemic stroke treatment. It aims to determine if maintaining a zero-degree head-of-bed (HOB) position early on can prevent worsening neurological symptoms.

Findings showed that keeping the head of the bed flat at a 0-degree angle significantly improves outcomes for patients with acute ischaemic stroke who are awaiting mechanical thrombectomy.

Questions:
1. What is the background to this study?
2. What was the study design and patient cohort?
3. What are your findings?
4. What are the next steps?

Recorded remotely from Memphis, 2024.

Support: This is an independent interview conducted by Radcliffe Cardiology.

Editor: Mirjam Boros
Videographer: Oliver Miles