ESC 24: Hot Line & Late-breaking Science Video Collection

Published: 15 August 2024

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Overview

What's hot at the ESC Congress 2024?

Stay ahead of the curve with our faculty-led coverage of the European Society of Cardiology Congress in London. From groundbreaking trials to expert insights, we've got you covered.

  • Watch our View From the Thoraxcenter series for practice-focused reviews of the most anticipated trials from interventional experts, Prof Nicolas Van Mieghem and Dr Joost Daemen. 
  • For a deeper dive into key hot line clinical trial data and its applicability, host, Dr Harriette Van Spall meets with principal investigators in her Late-Breaker Discussion series.
  • View a condensed summary of the crucial takeaways from each day in our Wrap-Up series led by Dr Mirvat Alasnag.
  • Our short, bite-sized Expert Interviews with select faculty will focus on data, take-home messages for practice and the future of their field.

Get ready for a deep dive into the latest cardiology research. Our coverage of the ESC Congress is coming soon.

More from this programme

Part 1

View From the Thoraxcenter: What's Hot at ESC 24?

2 sessions
ESC Congress 2024 Hot Line Wrap Up Watch now
ESC Congress 2024 Hot Line Preview Watch now

Part 2

Daily Wrap Ups with Dr Alasnag and Dr Al-Shaibi

4 sessions
ESC Day 1 Wrap Up: New Guidelines, HELIOS-B, ABYSS & STOP-or-NOT Watch now
ESC Day 2 Wrap-Up: NOTION-3, RESHAPE-HF2, TRI.Fr & More Watch now
Day 3 Wrap-Up with Dr Alasnag and Dr Al-Shaibi Watch now
Day 4 Wrap-Up: OCCUPI, REC-CAGEFREE I, AEGIS-II & More Watch now

Part 3

Hot-line Discussions with Dr Harriette Van Spall

5 sessions
AβYSS: Beta Blocker Interruption After Uncomplicated MI Watch now
RHEIA: TAVR vs SAVR in Women with Severe AS Watch now
OCEANIC-AF: Asundexian Vs Apixaban in Atrial Fibrillation Watch now
SWEDEGRAFT: No-touch Vein Graft in CABG Watch now
FINEARTS-HF: Finerenone HFmEF & HFpEF Watch now

Part 4

Expert Interviews

13 sessions
Bridging the Gap in Heart Failure Guideline Implementation from a Specialist Nurse Perspective Watch now
MATTERHORN: M-TEER vs Surgery in Heart Failure Watch now
MRAs in Heart Failure Watch now
FINE-HEART: Finerenone in HF & CKD Watch now
STEEER-AF: Stroke Prevention & Rhythm Control Therapy Watch now
NOTION-3: FFR Guided PCI in TAVI Watch now
EPIC-CAD: Edoxaban vs Dual Antiplatelet Therapy in AF & CAD Watch now
SENIOR RITA: Invasive Vs Conservative Strategy for Older Patients with MI Watch now
EARTH-STEMI: Complete Vs Culprit-Only Revascularization in Older Patients Watch now
SCOFF: Fasting vs. Non-Fasting: Impact on Cardiac Catheterization Outcomes Watch now
GUARD-AF: Atrial Fibrillation Screening to Reduce Stroke in Elderly Individuals Watch now
SHAM-PVI: Sham Study of Pulmonary Vein Isolation in Symptomatic Atrial Fibrillation Watch now
POPular PAUSE TAVI: Continuation or interruption of OAC During TAVI Watch now

Part 5

Highlights

2 sessions
3 Trials That Will Change My Practice With Dr Muthiah Vaduganathan Watch now
3 Trials That Will Change My Practice With Dr Michelle Kittleson Watch now

Part 6

Guidelines

2 sessions
New Guidelines for the Management of Atrial Fibrillation Watch now
New Guidelines for the Management of Aortic Diseases Watch now

About the episode

ESC Congress 24 — AF screening with a wearable ECG device increases diagnosis by over 50% but did not significantly reduce hospitalisation rates for stroke.

We are joined onsite at ESC Congress 2024 by Dr Renato Lopes (Duke University Medical Center, NC) to discuss the findings from the GUARD-AF Trial (NCT04126486, Bristol-Myers Squibb), which was designed to determine if screening for undiagnosed atrial fibrillation (AF) or atrial flutter (AFL) in patients aged 70 and above can reduce the incidence of strokes as compared to those receiving standard of care without screening. The trial involved 11,931 participants across 176 locations, and used the Zio® XT monitor to detect AF or AFL.

The primary outcome of the GUARD-AF study is to measure the incidence of all strokes leading to hospitalization, comparing the effectiveness of the Zio® XT monitor intervention in detecting undiagnosed atrial fibrillation (AF) or atrial flutter (AFL) against usual care without screening. Secondary outcomes include the incidence of bleeding events leading to hospitalization. These outcomes are assessed over a period of 2.5 to 5 years, aiming to determine whether early detection and management of AF or AFL can significantly reduce the risk of stroke and monitor any associated risks such as bleeding.

Findings showed that over a median follow up of 15 months, a 52% increase in cases of atrial fibrillation were diagnosed over a maximum of 2.5 years of follow-up, an increase in uptake of oral anticoagulants, no increase in hospitalisation rates and no significant reduction in stroke hospitalisation as compared to usual care. It should be noted that these results cannot be considered conclusive, as the trial was stopped early due to the COVID-19 pandemic. 

Interview Questions:

  1. How can atrial fibrillation or atrial flutter contribute to stroke risk in elderly individals?
  2. Can you tell us about the study design and patient population?
  3. What were the key findings?
  4. How should these findings impact clinical practice?
  5. What further research is needed, and what are the next steps?

Recorded on-site at ESC Congress 2024, London.

Editors: Jordan Rance and Mirjam Boros.
Videographers: Mike Knight, Dan Brent, Oliver Miles, Tom Green, David-Ben-Harosh.

Support: This is an independent interview produced by Radcliffe Cardiology.

Faculty Biographies

Renato D Lopes

Renato D Lopes

Professor of Medicine

Dr Renato D Lopes is currently the Director of Clinical Events Classification (CEC) and the Co-Director of the Integrated Clinical Events-Safety Surveillance Group. His primary research interests include investigating the impact and outcomes of atrial fibrillation complicating acute coronary syndromes.

Dr Lopes completed his clinical training at the Federal University of São Paulo, and his Cardiology Fellowship at the Duke Clinical Research Institute (DCRI), serving as Chief Fellow for the research training program during his senior year. 

View full profile

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