ESC Congress 24 — OCCUPI trial finds OCT-guided PCI more effective than angiography-guided PCI in reducing heart-related events.

We are joined onsite at ESC 24 by Dr Kim Byeoung-Keuk (Yonsei University College of Medicine, Seoul, SK) to discuss the results of the OCCUPI trial (NCT03625908), which aims to evaluate the clinical benefits of optical coherence tomography (OCT)-guided percutaneous coronary intervention (PCI) as compared to angiography-guided PCI in patients with complex coronary artery lesions. This randomized controlled trial enrolled 1604 participants, who were assigned to either an OCT-guided or angiography-guided PCI. Within the OCT arm, patients were further divided into groups receiving full OCT-Guidance, or post-procedural OCT only.

The primary outcome is incidence of major adverse cardiac events (MACE) at one-year post PCI. Secondary outcome measures include cardiac events, stent optimization, and procedural complications.

OCT-guided PCI was found to be more effective than angiography-guided PCI in reducing the risk of heart-related events, including death, heart attack, ST-segment elevation, and target vessel revascularization.

Interview Questions: 

1. What is the importance of this study?
2. Please tell us about the study design and patient population
3. What are the key findings?
4. How should the findings of this study impact clinical practice?
5. What further research is needed, and what are the next steps?

Recorded on-site at ESC Congress 2024, London.

Editors: Jordan Rance and Mirjam Boros.
Videographers: Mike Knight, Dan Brent, Oliver Miles, Tom Green, David-Ben-Harosh.

Support: This is an independent interview produced by Radcliffe Cardiology.