Exploring Therapeutic Mechanisms to Improve Organ Function in CVRM Diseases

Published: 02 October 2024

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Overview

First presented at EASD 2024, this on-demand programme sees Prof Hiddo Heerspink lead a distinguished faculty comprising of Prof Carel le Roux and Prof Ildiko Lingvay
 

This symposium features vital discussions on the effects of GLP-1–weight loss mediated versus direct action and the mechanistic synergies of the actions of SGLT2 inhibitors and GLP-1 agonists on organ function.
 

Date of Prep: September 2024
Z4-69899

This non-promotional programme is organised and fully funded by AstraZeneca.

Key Learning Objectives

  • Understand the different mechanisms by which GLP-1 agonists achieve their beneficial effects including weight loss, glycaemic control and direct receptor activation
  • Appreciate the mechanisms by which GLP-1 agonists and SGLT2 inhibitors protect major organs
  • Understand how the mechanistic synergies of combination therapy with a GLP-1 receptor agonist plus an SGLT2 inhibitor may improve treatment outcomes

Target Audience

  • General Cardiologists
  • Primary Care Physicians
  • Diabetologists
  • Endocrinologists

More from this programme

Part 1

Chair Welcome and Introduction

Part 2

Beneficial Effects of GLP-1 RAs: Weight Loss Mediated or Direct Action?

Part 3

Mechanistic Synergies of the Actions of SGLT2 Inhibitors and GLP-1 RAs on Heart and Liver

Part 4

Mechanistic Synergies of the Actions of SGLT2 Inhibitors and GLP-1 RAs on Kidney Protection

Part 5

How Can We Utilise the Mechanistic Insights to Further Improve Treatments of Patients?

Faculty Biographies

Hiddo Heerspink

Hiddo Heerspink

Clinical Pharmacologist

Prof Hiddo Heerspink’s is a Clinical Pharmacologist at the Department of Clinical Pharmacy and Pharmacology at the University Medical Center Groningen, the Netherlands. he also serves as a Visiting Professor at the University of New South Wales in Sydney, Australia. Prof Heerspink's research interests include treatment strategies and therapeutic approaches for the treatment of renal and cardiovascular disease in patients with diabetes.

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Carel le Roux

Carel le Roux

Head of Pathology

Prof Carel le Roux is Head of Pathology at University College Dublin, Dublin, IE.

He graduated from medical school in Pretoria South Africa, completed his Senior House Officer training at Barts and The London Hospital, his SpR training in metabolic medicine at the Hammersmith Hospitals and his PhD at Imperial College London.

Working within the Diabetes Complications Research Centre and the Section of Surgery and Surgical Specialities, the focus of Prof le Roux's research is primarily concerned with increased mortality and morbidity associated with obesity and diabetes.

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Ildiko Lingvay

Ildiko Lingvay

Endocrinologist

Dr Ildiko Lingvay is an Endocrinologist and Professor in the Department of Internal Medicine at UT Southwestern Medical Center, Texas, US.

Dr Lingvay earned her medical degree with honors at the University of Medicine and Pharmacy in Bucharest.

She specialises in clinical research in the fields of obesity, diabetes, and metabolic complications. Her research interests include metabolic syndrome, obesity, and diabetes mellitus.

 

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