In this Meet the Experts session, from e-SPACE Cardio-Renal-Metabolic 2024, join Dr Gianluigi Savarese (Karolinska Institute, SE) and Prof James Burton (University of Leicester, UK) as they discuss optimising RAAS inhibitor therapy in patients with chronic kidney disease and the challenge of guideline-directed medical therapy (GDMT) implementation in patients with heart failure and comorbidities.