Summary: R. De Palma leads A. Chieffo and G. Stankovic through an i n-depth discussion tracing the contours of this challenging topic. What are the criteria pointing to the two-stent approach? And where do you begin in treating your complex les ions, the main branch or the side branch? When is adjunctive imaging advised? These and other q uestions are discussed in this wide-ranging discussion including indication s in non-left main bifurcations, what the differences are in treating the left main and what data are available t oday concerning this strategy in the Left Main ... . Are further trials planned?