A Review of Emerging ARNI Data in HFrEF

Published: 27 November 2019

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Overview

Despite advances in cardiovascular therapy, heart failure (HF) continues to be a leading cause of morbidity and mortality with significant cost to the health care system. Evidence for the angiotensin receptor-neprilysin inhibitor (ARNI) sacubitril/valsartan has demonstrated significant reductions in all-cause mortality, cardiovascular mortality, and HF hospitalization compared with enalapril and international guidelines currently recommend its use.

Despite this evidence and the recommendation of clinical guidelines, ARNI therapy is not initiated in the majority of eligible patients. Evidence suggests a lack of understanding of a patient’s risk and also the benefit of life saving therapies by physicians is a primary cause of under-utilization.

Increased education is needed so clinicians fully understand the patient’s risk, as well as latest mechanistic and clinical data to ensure confidence in using newer therapies.

This educational program summarises new data covering ARNI therapy for heart failure with reduced ejection fraction (HFrEF) presented at the European Society of Cardiology (ESC) 2019 congress.
 

EBAC Accreditation

This video series was funded by an unrestricted educational grant from Novartis.

Educational Objectives

  • Review updated data of ARNI therapy for HFrEF present at the ESC 2019
  • Understand the current utilisation of ARNI therapy in HFrEF (guidelines and databases)
  • Interpret potential mechanistic data related to the clinical benefit of ARNI therapy including imaging and biomarker data
  • Apply new data covering the utilization of ARNI therapy in complex patients including recently decompensated and hospitalized patients.

More from this programme

Part 1

ARIADNE in Review

In this video, Prof Uwe Zeymer (Klinikum Ludwigshafen, Ludwigshafen, DE) discusses the ARIADNE trial - understanding the current utilization of Angiotensin Receptor-Neprilysin Inhibitor (ARNI) therapy in HFrEF.
1 session
ARIADNE in Review Watch now

Part 2

Commentary on ARIADNE

In this video Prof Scott Solomon (Harvard Medical School, MA, US) and Prof Andrew Coats (University of Warwick, UK) discuss the ARIADNE trial.
1 session
Commentary on ARIADNE Watch now

Part 3

PROVE-HF in Review

In this video, Prof James Januzzi (Harvard Medical School, MA, US) presents a comprehensive review of PROVE-HF - Interpreting potential mechanistic data related to the clinical benefit of ARNI therapy including imaging and biomarker data.
1 session
PROVE-HF in Review Watch now

Part 4

EVALUATE in Review

In this video, Prof Akshay Desai (Harvard Medical School, MA, US) presents a comprehensive review of EVALUATE-HF.
1 session
EVALUATE in Review Watch now

Part 5

Commentary on PROVE-HF and EVALUATE

In this video Prof Scott Solomon (Harvard Medical School, MA, US) and Prof Andrew Coats (University of Warwick, UK) discuss the PROVE-HF and the EVALUATE-HF trials.
1 session
Commentary on PROVE-HF and EVALUATE Watch now

Part 6

TRANSITION-CHF in Review

In this video, Prof Rolf Wachter (Leipzig University Hospital, Leipzig, DE) presents a comprehensive review of TRANSITION-CHF.
1 session
TRANSITION-CHF in Review Watch now

Part 7

PIONEER in Review

In this video, Prof David A Morrow, Professor of Medicine and Cardiology from the Harvard Medical School, Boston, MA, US, discusses the emerging data on utilising Angiotensin Receptor-Neprilysin Inhibitor (ARNI) therapy in complex patients.
1 session
PIONEER in Review Watch now

Part 8

Commentary on TRANSITION-CHF and PIONEER

In this video Prof Scott Solomon (Harvard Medical School, MA, US) and Prof Andrew Coats (University of Warwick, UK) discuss the TRANSITION-CHF and the PIONEER trials.
1 session
Commentary on TRANSITION-CHF and PIONEER Watch now

Faculty Biographies

Akshay S Desai

Akshay S Desai

Prof Akshay Desai is a cardiovascular medicine specialist and the director of the Cardiomyopathy and Heart Failure Program at Brigham and Women’s Hospital. Dr Desai’s research focuses on improving care and outcomes for HF patients, as well as strategies to reduce heart failure readmissions. 

Prof Desai received his medical degree from HMS. He completed an internal medicine residency as well as fellowships in cardiovascular medicine, vascular medicine and advanced heart disease at BWH. He is board certified in and cardiovascular disease, as well as advanced heart failure and transplant cardiology.

His clinical interests include advanced heart failure, cardiomyopathies (myocarditis, amyloidosis, sarcoidosis), congenital heart disease and cardiac transplantation. His research has received support from the American College of Cardiology and the National Heart, Lung and Blood Institute.

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