In this Meet the Experts session, from e-SPACE Cardio-Renal-Metabolic 2024, Prof Michel Jadoul (Université catholique de Louvain, BE), Prof Clara Inés Saldarriaga (University of Antioquia, CO) and Prof Shelley Zieroth (St. Boniface Hospital, CA) discuss the optimal use of SGLT2 inhibitors in heart failure, diabetes and chronic kidney disease.