Transforming TAVI Practice: Evidence, Equity and Durability
Published: 17 September 2024
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6453
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Views:
6453
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Likes:
7
Overview
This video series includes a symposium first presented at ESC 2024 held in London, where Prof Roxana Mehran, Prof Vijay Kunadian, Dr Didier Tchetche, Dr Julia Grapsa and Dr Joanna J Wykrzykowska discuss transforming TAVI practice. The discussion covers topics such as the SMART trial, a comparison of the most commonly used TAVI valves and strategies to address disparities in diagnosing aortic stenosis in women.
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Learning Objectives
- Gain insights on the landmark SMART trial, comparing the most used TAVI valves and discuss clinical implications
- Discover how to address disparities in aortic stenosis diagnosis and treatment of women
- Interpret the latest data on TAVI valve durability and predictors of valve longevity
Target Audience
- General Cardiologists
- Interventional Cardiologists
More from this programme
Part 1
Prof Roxana Mehran Interview
Prof Mehran summarises the key learnings from the scientific session.
| 1 session | |
| Prof Roxana Mehran Interview | Watch now |
Part 2
Welcome and Introduction
Welcome and introduction of the presenters and learning objectives by Prof Mehran and Prof Kunadian.
| 1 session | |
| Welcome and Introduction | Watch now |
Part 3
SMART Trial Results
Dr Tchétché presents the results of the SMall Annuli Randomized To Evolut or SAPIEN Trial (SMART Trial). The largest, most rigorous trial to date to randomise patients to the two most widely used TAVI devices and the largest TAVI trial to enrol mostly women. It includes a panel discussion on low-flow low gradient aortic stenosis patients and differences in Balloon-Expandable versus Self-Expandable Valves.
Part 4
Addressing Underdiagnosis in Women With Aortic Stenosis
Dr Grapsa presents the challenge of treating women with aortic stenosis, a common clinical scenario and the differences in clinical presentation between women and men. The session includes how to address underdiagnosis in women including sex specific imaging considerations. The panel discuss early diagnosis, referral of women with aortic stenosis and strategies to adopt to fine tune treatment to a female patient.
Part 5
Durability in TAVI Valves
Dr Wykrzykowska presents durability in TAVI valves, Bioprothetic Valve Dysfunction causes and types. She presents data and long-term follow-up from the Evolut™ TAVI low risk trial, PARTNER 3 trial and NOTION trial and also shares the SMART trial results and predictors. Re-intervention and real world insights from case studies are discussed alongside the panel discussion on valve durability, the need for re-intervention putting into prospective life expectancy and durability of the valve.
Part 6
Take Home Message
Prof Kunadian summarises the scientific session and shares the take home messages.
| 1 session | |
| Take Home Message | Watch now |
Faculty Biographies
Roxana Mehran
Professor of Medicine, Cardiology and Professor of Population Health Science and Policy
Roxana Mehran is Professor of Medicine, Cardiology and Professor of Population Health Science and Policy at the Icahn School of Medicine at Mount Sinai in New York. She is also Director of Interventional Cardiovascular Research and Clinical Trials at The Zena and Michael A Weiner Cardiovascular Institute at Mount Sinai Hospital where, over the past 5 years, she has led the development of a globally respected data and clinical coordination centre to support large, multicentre, multinational clinical trials designed to help improve outcomes and quality of life for patients undergoing interventional cardiovascular procedures. In recent years, her work has had a special emphasis on gaining a deeper understanding of anticoagulation and antiplatelet regimens post angioplasty and transcatheter valve replacement; and collection and interpretation of sex-specific data in cardiovascular clinical trials.
Roxana serves on editorial board of multiple peer reviewed journals, including …
Vijay Kunadian
Professor of Interventional Cardiology
Prof Vijay Kunadian is Personal Chair and Professor of Interventional Cardiology at Newcastle University.
Prof Kunadian completed all her cardiology training in the North East of England. She undertook an international academic fellowship in cardiology at the TIMI/PERFUSE Study group, Brigham and Women’s Hospital/Harvard Medical School, Boston MA.
Prof Kunadian has an international reputation in interventional cardiology and cardiovascular research, making her a sought-after and respected speaker at prominent national and international meetings. She has championed diversity in her specialty as a role model; only 5% of interventional cardiologist are female in the UK, <1% are clinical academics.
Didier Tchétché
Didier Tchétché, (Clinique Pasteur, Toulouse, France) Graduated from the University of Paris V where Dr Tchétché obtained his post-graduate diploma of cardiovascular pathology in 2004. From 2004 to 2005, he completed a 12-month fellowship period in the Hemodynamic and Interventional Cardiology department of Clinique Pasteur in Toulouse and from 2005 to 2007 he was Head Assistant at the intensive care unit of Bichât Hospital in Paris.
In 2008, he joined the interventional cardiovascular group in Clinique Pasteur, Toulouse, and he is currently Head of the Structural programme with an experience of more than 5000 TAVI procedures. His main areas of interest are coronary interventions and valvular heart disease. He has been actively involved in many clinical trials involving new technologies and devices in the field of interventional cardiology.
Julia Grapsa
Consultant Cardiologist
Dr Julia Grapsa has been a Consultant Cardiologist at Guy's and St Thomas' NHS Foundation Trust in London, UK since March 2020, leading the imaging team for tricuspid services.
Dr Grapsa is editor-in-chief for JACC Case Reports, and is a fellow for the Royal College of Physicians, the European Society of Cardiology, the American Heart Association, EACVI, the American Society of Echocardiography and the American College of Cardiology.
Dr Grapsa graduated from the Medical School of Ioannia in Greece, and then went on to train at the Imperial College Healthcare NHS Trust and the Royal Brompton Hospital in London. Her research interests include Mitral Valve Prolapse, Mitral Annular Disjunction and Tricuspid Valve and right heart remodelling. She has received awards from the European Society of Cardiology, including the training and research grant and the young investigator award in 2013 for her research in pulmonary hypertension.
Dr…
Joanna J Wykrzykowska
Interventional Cardiologist
Dr Joanna J Wykrzykowska obtained her Doctor of Medicine degree from Harvard Medical School and Massachusetts Institute of Technology, Boston MA in 2002. She completed her internal medicine residency at the Massachusetts General Hospital and her Cardiology Fellowship at Beth Israel Deaconess Medical Center (both Harvard teaching hospitals). She continued and completed her Interventional Cardiology fellowship at Erasmus MC, Rotterdam NL in 2010 and obtained her PhD in interventional cardiology in 2011 under the supervision of Prof Patrick Serruys. She worked as staff Interventional Cardiologist at the Amsterdam University Medical Center till 2020 where she was the principal investigator of multiple clinical trials, including AIDA trial (published in NEJM).
Since 2020 Dr Wykrzykowska is an interventional cardiologist and since 2022 holds the title of an Associate Professor of Interventional Cardiology at the University Medical Center in Groningen.
Her research…