Transforming TAVI Practice: Evidence, Equity and Durability

Published: 17 September 2024

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Overview

This video series includes a symposium first presented at ESC 2024 held in London, where Prof Roxana Mehran, Prof Vijay Kunadian, Dr Didier Tchetche, Dr Julia Grapsa and Dr Joanna J Wykrzykowska discuss transforming TAVI practice. The discussion covers topics such as the SMART trial, a comparison of the most commonly used TAVI valves and strategies to address disparities in diagnosing aortic stenosis in women.

 

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Learning Objectives

  • Gain insights on the landmark SMART trial, comparing the most used TAVI valves and discuss clinical implications
  • Discover how to address disparities in aortic stenosis diagnosis and treatment of women
  • Interpret the latest data on TAVI valve durability and predictors of valve longevity

Target Audience

  • General Cardiologists
  • Interventional Cardiologists

More from this programme

Part 1

Prof Roxana Mehran Interview

Prof Mehran summarises the key learnings from the scientific session.

1 session
Prof Roxana Mehran Interview Watch now

Part 2

Welcome and Introduction

Welcome and introduction of the presenters and learning objectives by Prof Mehran and Prof Kunadian.

1 session
Welcome and Introduction Watch now

Part 3

SMART Trial Results

Dr Tchétché presents the results of the SMall Annuli Randomized To Evolut or SAPIEN Trial (SMART Trial). The largest, most rigorous trial to date to randomise patients to the two most widely used TAVI devices and the largest TAVI trial to enrol mostly women. It includes a panel discussion on low-flow low gradient aortic stenosis patients and differences in Balloon-Expandable versus Self-Expandable Valves.


 

1 session
SMART Trial Results – A Landmark Head-to-head Randomised Controlled TAVI Trial Watch now

Part 4

Addressing Underdiagnosis in Women With Aortic Stenosis

Dr Grapsa presents the challenge of treating women with aortic stenosis, a common clinical scenario and the differences in clinical presentation between women and men. The session includes how to address underdiagnosis in women including sex specific imaging considerations. The panel discuss early diagnosis, referral of women with aortic stenosis and strategies to adopt to fine tune treatment to a female patient.


 

1 session
Addressing Underdiagnosis in Women With Aortic Stenosis Watch now

Part 5

Durability in TAVI Valves

Dr Wykrzykowska presents durability in TAVI valves, Bioprothetic Valve Dysfunction causes and types. She presents data and long-term follow-up from the Evolut™ TAVI low risk trial, PARTNER 3 trial and NOTION trial and also shares the SMART trial results and predictors. Re-intervention and real world insights from case studies are discussed alongside the panel discussion on valve durability, the need for re-intervention putting into prospective life expectancy and durability of the valve.

1 session
Durability in TAVI Valves – Data, Predictors and Real-world Insights Watch now

Part 6

Take Home Message

Prof Kunadian summarises the scientific session and shares the take home messages.

1 session
Take Home Message Watch now

Faculty Biographies

Joanna J Wykrzykowska

Joanna J Wykrzykowska

Interventional Cardiologist

Dr Joanna J Wykrzykowska obtained her Doctor of Medicine degree from Harvard Medical School and Massachusetts Institute of Technology, Boston MA in 2002. She completed her internal medicine residency at the Massachusetts General Hospital and her Cardiology Fellowship at Beth Israel Deaconess Medical Center (both Harvard teaching hospitals). She continued and completed her Interventional Cardiology fellowship at Erasmus MC, Rotterdam NL in 2010 and obtained her PhD in interventional cardiology in 2011 under the supervision of Prof Patrick Serruys. She worked as staff Interventional Cardiologist at the Amsterdam University Medical Center till 2020 where she was the principal investigator of multiple clinical trials, including AIDA trial (published in NEJM).

Since 2020 Dr Wykrzykowska is an interventional cardiologist and since 2022 holds the title of an Associate Professor of Interventional Cardiology at the University Medical Center in Groningen. 

Her research…

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Roxana Mehran

Roxana Mehran

Professor of Medicine, Cardiology and Professor of Population Health Science and Policy

Roxana Mehran is Professor of Medicine, Cardiology and Professor of Population Health Science and Policy at the Icahn School of Medicine at Mount Sinai in New York. She is also Director of Interventional Cardiovascular Research and Clinical Trials at The Zena and Michael A Weiner Cardiovascular Institute at Mount Sinai Hospital where, over the past 5 years, she has led the development of a globally respected data and clinical coordination centre to support large, multicentre, multinational clinical trials designed to help improve outcomes and quality of life for patients undergoing interventional cardiovascular procedures. In recent years, her work has had a special emphasis on gaining a deeper understanding of anticoagulation and antiplatelet regimens post angioplasty and transcatheter valve replacement; and collection and interpretation of sex-specific data in cardiovascular clinical trials.

Roxana serves on editorial board of multiple peer reviewed journals, including …

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